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Microbiome: why gut flora is important


From digestion to depression, healthy skin and a strong immune system, our gut health has a say of what goes on elsewhere in our bodies. So, why is the gut still considered by many people to be nothing but an organ? Gut microbiome’ and microbiota’ are indeed becoming buzzwords, with which many of us are now becoming familiar. Although the extent to which our gut influences our health all over our bodies is slowly coming to light,  some experts believe that this is just the tip of the iceberg. Find out why.

Our gut is home to a hefty 100 trillion bacteria that influence our health and well-being – and even our mood. Our gut flora (also called the microbiome or microbiota) is important for digestion, defence against dangerous germs and toxins, and strengthening the immune system. Experts now link various diseases, allergies and even depression to the fact that the intestinal flora is out of balance.[1]

In Japan, people regard the gut as the centre of physical and mental strength in our bodies. In this part of the world, however, our guts are often still considered a purely digestive organ – and is thus grossly underestimated. Flatulence, diarrhoea and constipation are taboo subjects, and digestive disorders represent roughly 10 per cent of GPs’ workload – although it is believed that many people avoid making appointments with their doctor for such health issues. This suggests that gut health and digestive health do not appear high on the priority list for many patients across the United Kingdom.[43]

The bacteria in our guts that make up our intestinal flora not only contribute to healthy digestion. They also protect us from diseases and strengthen the immune system. Our intestinal bacteria influence whether we get neurodermatitis, develop an inflammatory bowel disease or tolerate certain foods.

So, it goes without saying that the gut microbiome demands a lot more attention than we give it. Find out how to achieve a healthy gut, take the right probiotics and boost your immune system in our latest article on gut health!


What does gut health mean?

What does it mean to have a healthy gut? There may be more to it than meets the eye. Leading scientists have defined five criteria that constitute good gut health, including:[1]

  • no intestinal diseases
  • effective digestion and absorption of food
  • normal and stable intestinal flora
  • a strong immune system
  • general well-being

Among other things, your intestine also influences whether you have an intolerance or allergy to certain foods or substances, such as lactose.

Did you know that, at 5 to 7.5 metres in length, the intestine is our largest internal organ?

How can I improve my gut health?

Gut flora is complex, and scientists have by no means solved all the mysteries surrounding it. However, there are some ways you can support your microbiome, according to the latest research:[2]

  • exercise regularly
  • avoid chronic stress
  • eat a healthy diet that is high in fibre and low in sugar, saturated fats and processed foods
  • take probiotics and prebiotics, if necessary 

How do you know if you have a healthy gut?

Is your microbiome healthy? That’s not always an easy question to answer. But there are some symptoms that indicate gut problems, such as a bloated stomach or frequent diarrhoea.

Conversely, there are also signs that indicate a healthy microbiome:

    • bowel movements once to three times a day
    • well-formed stool
    • flat, not bloated abdomen
    • little flatulence
    • no complaints after eating certain foods

    What is the function of our gut?

    Our intestines are constantly busy processing food and fighting off pathogens. The most important phase of digestion takes place in the small intestine. It digests our food until all the important nutrients, vitamins and minerals have been absorbed. The rest of the food enters the large intestine, from which it is excreted.[3]

    Did you know that, from absorption in our mouths to our large intestine, food stays in our body for five to 70 hours?[4]

    But the gut has another function that has been underestimated for years: promoting a healthy immune system. The digestive tract constantly fends off pathogens such as bacteria, viruses, fungi, environmental toxins and toxins.

    our microbiome is considered to be at the heart of immune system health

    How do you fix a bad gut?

    If there is an imbalance between the different types and strains of bacteria and the immune system, this weakens the defences in our gut. The result can be:[4]

    • gastrointestinal problems such as constipation, diarrhoea and even inflammation
    • intestinal diseases
    • tendency to be overweight
    • generally weakened defences and thus more frequent infections

    Problems in the gastrointestinal tract can also be an indication of allergies and intolerances. To investigate this, analysing a blood sample (for example, with a food intolerance and food allergy test) for certain antibodies may be useful.

    The gut as the second brain

    The gut is also home to a nervous system that contains more neurones than the entire spinal cord. Scientists realised 100 years ago that bacteria in the gut constantly communicate with neurones in the brain. This is how our guts have gained recognition as our second brain. This is arguably how the phrase gut feeling’ came into the picture, referring to intuitions triggered by a second brain.[1, 3]

    What is gut flora?

    Up to 100 trillion different organisms such as bacteria, viruses and fungi live in your gut. These microorganisms are collectively called the gut flora or microbiome.

    Most of the bacteria are located where the digestion process is almost over, in the intestinal mucosa of the colon.[5] If the process is impaired, and the bacteria migrate from the large to the small intestine, the result can be severe flatulence, abdominal pain, joint pain, nutrient deficiencies and anaemia. This still partly unexplored health issue is called bacterial overgrowth.[6]

    Bacterial colonisation can occur, for example, if you take broad-spectrum antibiotics. Broad-spectrum antibiotics are drugs that are effective against many types of bacteria and are often used for dangerous diseases.[6]

    What does the gut microbiome affect?

    Bacteria are not always harmful. In fact, gut bacteria is essential for human survival. Among other things, the gut microbiome plays a very important role in the digestion of food.

    The good bacteria of the intestinal flora, which are vital for our body, have numerous other functions, for example:[9, 10]

    • They produce what is known as butyrate from our food, which has been shown to contribute to good gut health by promoting mechanisms to combat stress
    • They produce a number of essential amino acids
    • They produce certain vitamins, such as vitamin K and water-soluble B vitamins

    A study published in the journal Science revealed that gut microbiome can block allergic reactions. Through their influence on our immune system, they can inhibit immune cells that are responsible for triggering allergies. This connection could be an approach for new treatment options for allergy sufferers in the future.[11]

    Gut flora and immune system health

    There are many complex connections between the gut microbiome and the immune system. A total of 70 to 80 per cent of the cells of our immune system are located in the intestine. The microbiome thus plays an important role in protecting the body from pathogens and inflammation.[2]

    To promote our body’s defence, information is constantly exchanged between the immune system and good bacteria. These healthy bacteria include above all the genera of lactobacilli and bifidobacteria, which also make up a large part of the intestinal flora.

    Curious to find out more about our immune system? Head over to our article on boosting immune system health to gain more insights into immune system boosters, including supplements, vitamins and more.

    What can weaken the immune system in our gut?

    If there are fewer good bacteria and bad bacteria begin to dominate, inflammation can spread more easily, and pathogens can penetrate the body more easily.

    Such an imbalance (dysbiosis) of the gut microbiome can occur, among other things, due to an unhealthy diet with a lot of saturated fats and sugar or after a course of antibiotics.[7]

    What causes an imbalance in gut flora?

    The composition of the gut flora is different for every person and changes over the course of a lifetime. Over the last 20 years, researchers have been able to identify patterns by which a healthy gut can be recognised. Nevertheless, a large part of the functions performed by our gut microbiome is still unknown.[12].

    What is known so far is that there are factors that continuously influence the composition of gut bacteria. These are age, gender and genetic predisposition – but above all, diet. You can influence which bacteria colonise your intestine yourself through your food choices.[13]

    Unhealthy microbiome can lead to bloating

    What causes an unhealthy gut?

    How does bacterial colonisation become imbalanced? There are many possible causes. Some of the most common are:[14]

    • Contact with environmental toxins and poisons
    • Poor diet (few anti-inflammatory foods)
    • Smoking cigarettes
    • Taking certain medicines like antibiotics
    • Long-term stress
    • Infection with harmful pathogens

      How do antibiotics affect the microbiome?

      Antibiotics have brought us progress in fighting bacterial infections and thus dangerous diseases. But they also have their downsides – from diarrhoea to an inflamed colon (and occasionally an inflamed small intestine) are the most common and noticeable side effects of antibiotics.[15]. In addition, antibiotics affect our gut flora – a side effect that you will not necessarily notice. With long-term use, the ratio of good bacteria to bad bacteria shifts and becomes imbalanced.[16]

      Did you know that, according to a projection, global antibiotic consumption has risen by 65 per cent in the last 15 years?[17]

      Antibiotics are made to kill bacteria – in this way, they help against dangerous bacterial infections. However, they do not only fight harmful bacteria, but also good intestinal bacteria. They also leave behind a lot of dead bacteria in the intestines, which we have to get rid of by having more frequent bowel movements. Our gut flora then has to be restored, which takes time. Through a targeted diet, we can nourish our bodies with bacteria-friendly food and accelerate the growth of a healthy gut microbiome.[16]

      The World Health Organization considers antibiotic resistance to be one of the greatest threats to health worldwide. Bacteria become immune to antibiotics, so that deadly diseases can no longer be treated with them. One reason for resistance is that too many antibiotics are prescribed for colds.[18–20]

      Gut health: how do I increase good gut bacteria?

      Studies clearly show that our diet also influences our gut flora. What we eat plays an essential role in maintaining the biodiversity and function of our gut flora. This is because our bacteria feed on what we give them through our diet. In order to make your diet gut-friendly and balanced, getting professional nutritional advice may be worthwhile.

      How do I boost my gut health?

      Enjoy coffee, black tea or alcohol only in moderation. Coffee and alcohol have a strong laxative effect in high quantities, while black tea causes constipation.

      Opt for eating several small meals per day. Too much food at once overloads our digestive system. Eat at regular times and only when you feel hungry. Stop eating when you feel full.

      Make sure you drink enough fluids. It is best to drink still mineral water or  herbal tea. This softens the stool so that no constipation occurs and the bowels are emptied without any issues.

      Avoid ready-made products! They contain additives that are not tolerated by everyone and can cause discomfort. Avoid sauces and batters as much as possible, especially if they contain a lot of fat. They are difficult to digest and can cause abdominal pain and diarrhoea. Also avoid high-fat, high-sugar and high-protein foods.

      Make sure you chew thoroughly! This makes it easier for the intestines to absorb the food, leading to fewer complaints such as constipation, flatulence and heartburn.

      Eat fibre-rich foods such as whole grains, oatmeal and flaxseed. Your stools will be looser, and more harmful substances can be eliminated. Fibre is also crucial for our all-important gut microbiome. Five portions of fruit and vegetables a day are also good for your intestines. Besides vitamins and minerals, they also contain water and fibre.

      Make sure you get enough exercise. External movement is good for the internal movement in your gut.[27]

      Tip: If you want to make your diet richer in fibre, you should start with small amounts first. Otherwise, you may experience a lot of flatulence, which will lead to stomach pain. The intestines must first get used to a larger amount of fibre. This way, you can avoid the unpleasant consequences of flatulence.

      Gut health and weight loss

      Our gut bacteria metabolise the food we eat. They turn it into fats, vitamins and minerals that our body can use for a variety of functions. If the gut flora changes, the way our body processes food also changes. Recent studies show that this is why, for example, the composition of the gut flora changes significantly in people who are overweight.[1] Conversely, an imbalance of the intestinal flora also increases the risk of gaining weight.[28]

      In some studies, the bacterial strain Firmicutes was highly prevalent in overweight people. Firmicutes extracts energy from food particularly efficiently. The presence of Firmicutes means more excess energy is utilised and stored in fat deposits – thus increasing the likelihood of you putting on weight. In study participants with fewer Firmicutes, more food was not utilised for energy and was excreted again via the stool.[29]

      If you follow our tips for a healthy and gut-friendly diet, this can also have an effect on the colonisation of Firmicutes bacteria. If the Firmicutes bacteria strain is less prevalent, this may help you lose weight.

      Probiotics and prebiotics

      You can also heal the gut naturally by using probiotics, prebiotics and resistant starch. They can restore the healthy bacteria – especially in the colon. Probiotics and prebiotics not only support the formation of healthy bacteria, but also displace the bad bacteria in our intestines.[4] Probiotics come in the form of capsules, powder and drops, for example – you can find many probiotic products in our online shop.

      When the ratio of gut bacteria is out of balance, doctors call this dysbiosis. This means that there is an excessive amount of certain types of fungi, yeasts or bacteria that negatively affect the body. By consuming probiotic foods and food supplements (often in capsule form), you can restore balance.

      What are probiotics?

      Probiotics are living organisms (bacteria) that are added to many foods. Once in the gut, they contribute to a well-functioning gut microbiome. They absorb nutrients and fight infections.[6, 21] Probiotics are normally produced during the natural fermentation of foods. This is why they are found in yogurt, kefir and sauerkraut, for example. However, the process of fermentation is time-consuming – and is therefore often omitted in modern food production. As a result, many foods that are actually probiotic aren’t beneficial for gut health.[22]

      To promote healthy gut bacteria, it can be beneficial to include more probiotic foods in your diet.

      Studies suggest that probiotics can improve lactose intolerance, reduce diarrhoea, constipation and flatulence, lower cancer-promoting enzymes, help with vaginitis, mitigate food allergies and have a beneficial effect on atopic dermatitis.[4]

      Improving gut health with probiotic foods

      How can I get probiotics naturally?

      Generally, fermented foods – that is, those produced by fermentation – contain probiotics. The following foods are commonly probiotic and can support your gut microbiome:

       Probiotic foods
      Kefir – contains ten to 34 probiotic strains, even more than yogurt
      Yogurt – produced with milk from organic farming
      Apple vinegar – contains healthy acids that support the function of probiotics
      Miso – Japanese paste made from fermented soybeans
      Kombucha – fermented tea with antibacterial effect
      Kimchi – fermented Chinese cabbage with garlic, ginger and chilli
      Sauerkraut – freshly prepared so that it still contains the lactic acid bacteria
      Cheese – mozzarella, cheddar and Gruyère, in particular, contain probiotics
      Gherkins – only the variety fermented in brine

      Are probiotic drinks actually good for you?

      In recent years, many probiotic drinks have been advertised as particularly healthy. In 2012 the new European regulation on such health claims forced manufacturers to withdraw some of their advertising claims. This has unsettled many people: how much do the probiotic drinks from brands like Yakult and Actimel actually contribute to good gut health?[23]

      Probiotic drinks and yogurts with added probiotics can definitely be useful. However, you should consider a few things when buying them:

        • The probiotic content decreases continuously after the drink/yogurt is bottled. The fresher the probiotic, the better.
        • The best-before date does not indicate when the food is off. After expiry, however, the product no longer contains the minimum number of bacteria that makes it probiotic.
        • Only 10 to 40 per cent of the lactic acid bacteria actually survive their passage through the stomach because of the stomach acid.
        • Beware of high sugar levels. Sugar serves as an energy source especially for the bad bacteria.

        How do I heal my gut after antibiotics?

        A few years ago, it was not recommended to take probiotics at the same time as antibiotics. Yogurt, kefir and sauerkraut were to be avoided during antibiotic treatment. It was thought that the antibiotic would kill the probiotics. Today, we know that probiotics can be very useful during antibiotic treatment to promote the formation of good gut bacteria. The best time to take probiotics is at least one hour before or two hours after taking the antibiotic.

        A clinical study investigated the effect of probiotics during antibiotic treatment. Of the study participants who took probiotics at the same time, 25 per cent fewer participants got sick with diarrhoea.[15]

        How many probiotics should I take?

        To ensure that enough viable bacteria reach the intestine, a dose should contain at least one billion colony-forming units (cfu). Due to stomach acid and bile, some bacteria do not survive the journey to the intestine. Therefore, higher doses also exist. Lactic acid-producing bacteria such as lactobacilli are particularly sensitive. For this reason, formulae with these bacterial strains often contain an enteric coating – for example, made of cellulose. If there is a specific health-related reason for taking probiotics, your doctor may recommend a certain dose of probiotics.[30]

        What are prebiotics?

        Prebiotics are dietary fibres that are not or only partially digestible. They are found in certain foods, including chicory, asparagus, leeks, onions and bananas. Prebiotics serve as direct nutrition for healthy bacteria in the colon and stimulate their growth. This creates healthy fatty acids and reduces intestinal pH. The best-known prebiotics are inulin and oligofructose.[21, 24]

        Did you know that there are also synbiotics? When probiotics and prebiotics are combined in one product (as a food supplement), they are usually called synbiotics. Synbiotics aim to increase the survival and activity of probiotics, as well as stimulate the bifidobacteria and lactobacilli gut bacteria.[25]

        What are resistant starches?

        ‘Resistant starch’ is the term used for starch and starch by-products. Resistant starch reaches the large intestine undigested, where it serves as a source of energy for the bacteria found there. It thus has physiological properties similar to dietary fibre:[26]

        • It improves gut health
        • It increases the amount of stool

          The following foods contain resistant starches

          Amount Food Resistant starches
          1 Banana (unripe) 4.7 grammes
          1/4 cup Oats (uncooked) 4.4 grammes
          1/4 cup Frozen peas (cooked) 4.0 grammes
          1/4 cup White beans (cooked) 3.7 grammes
          1/4 cup Lentils (cooked) 2.5 grammes
          Boiled potatoes (cooled) 2.4 grammes

          Test your gut health

          In stool tests, laboratories can determine which types of bacteria are present in the sample. They can analyse the composition of the different bacterial strains and the balance between good and bad bacteria.

          There are furthermore self-tests that examine the concentration of good bacteria in your gut. Such tests analyse the number of lactobacilli and bifidobacteria and thus give you an indication of which probiotics and foods you could best use to strengthen your gut flora.

          Some tests even give you a more profound insight into your gut health by additionally analysing the presence of individual species of the bacterial genera of lactobacilli and bifidobacteria, such as Lactobacillus reuteri and Bifidobacterium bifido. Modern DNA test methods are used for such tests.

          Food allergies and intolerances

          If symptoms occur mainly after meals or are particularly pronounced with certain foods, this can be an indication of an allergy or intolerance. In the case of an allergy, the symptoms are triggered by a malfunctioning immune system; an enzyme deficiency in the intestine often plays a role in intolerances.

          To discover more about the differences between a food allergy and intolerance, visit our dedicated Health Portal article. If you would like to test whether you are allergic to the most common food allergens in Europe, you should consider ordering a food allergy test today!

          How can I diagnose a food intolerance or allergy?

          Food allergies and intolerances can be tested in different ways. Allergies, for example, can be determined with the help of a blood test. The blood is analysed for IgE antibodies – too many of these antibodies indicate an allergy. You can also test for histamine intolerance by testing your blood for antibodies.

          Intolerances to lactose, fructose and sorbitol are usually tested with a hydrogen breath test.

          Gut health and illness

          The gut and the rest of your body are connected on many levels. It is therefore hardly surprising that imbalanced gut flora can also be linked with many diseases. This can affect gut health, but also, for example, the skin and our mental health.

          Gut flora and irritable bowel syndrome

          In the United Kingdom, it is estimated that about 20 per cent of the population suffer from irritable bowel syndrome – one of the most common chronic gastrointestinal diseases.[44]

          Recently, medical experts have recommended the administration of probiotics as a treatment option. Intestinal discomfort such as abdominal pain, flatulence, diarrhoea and constipation can be alleviated by taking probiotics.

          New studies have found that the gut flora of irritable bowel sufferers differs from that of healthy people. People with irritable bowel syndrome have imbalanced gut flora with a large number of bad bacteria. Doctors can select appropriate probiotics depending on symptoms.[31]

          Gut health and inflammatory bowel disease

          The chronic inflammatory bowel diseases Crohn’s disease and ulcerative colitis have become a worldwide problem since the beginning of the 21st century.[32] To date, scientists cannot say exactly what triggers these intestinal inflammations.

          Science agrees on one thing: our gut flora is a piece of the puzzle when it comes to the development of intestinal inflammation.[33, 34] Studies show that the intestinal flora of both people with Crohn’s disease and ulcerative colitis contains significantly more bad bacteria than good ones, and bacterial diversity is lower. This imbalance can impair the immune system, presumably leading to greater inflammation.[35, 36]

          Scientific studies have just delivered promising results for the treatment of ulcerative colitis: the protective bacteria bifidobacterium and lactobacillus could improve gut flora as probiotics and alleviate disease symptoms. [25, 37, 38]

          Gut health and depression

          Our brain contains billions of neurones that are closely linked with the trillions of good and bad gut bacteria. The gut flora transmits signals to the neurones in our brain. In stressful situations, the gut flora can actually change, which may have something to do with this collaboration between neurones and our gut microbiome.[39]

          This has led scientists to suspect that probiotics could reduce the symptoms of depression. The assumption was confirmed in a study in 2016 – however, this was the first review of this kind.[40] A 2011 study published in the journal Nature also showed impressive results – feeding healthy mice probiotics helped reduce anxiety-like and depressive behaviour compared to control mice. Future studies must show whether these results can be seen in humans.[41]

          Gut health and neurodermatitis

          Not only do numerous bacteria live in our gut – the skin also has its own bacterial ecosystem. As in the intestine, there are microorganisms here that are classified as particularly useful, neutral and/or pathogenic.[42] Scientists are currently investigating whether they can help people with neurodermatitis by influencing the bacteria of the skin via the gut flora. In this way, good gut health could also protect the skin.

          A study analysis published in 2019 concluded that probiotics can help reduce the risk of atopic dermatitis in children. It did not matter whether the mother took the probiotics during pregnancy or the child received them from an early age.[30]

          Gut health and complexion: little is known about the effectiveness of probiotics and prebiotics in cosmetic products. It is possible that they stimulate the growth of beneficial bacteria when applied directly to the skin. Researchers are still investigating this in further studies.[42]

          Maintaining a healthy gut microbiome – at a glance

          What does gut health mean?

          Our gut is healthy when there are no diseases in the intestine, no food intolerances or allergies, no unstable intestinal flora and no high susceptibility to infections.

          What is gut flora?

          The human gut is home to 100 trillion different microbial organisms, including bacteria, viruses and fungi. Together, these microorganisms form the gut flora, also called the microbiome. Most of the gut flora consists of bacteria.

          What is the function of gut flora?

          The bacteria in the gut strengthen our immune system, protect us from pathogens, produce important amino acids, vitamins and butyric acid. 

          What causes an unhealthy gut?

          There are various reasons why your gut may not be healthy. Possible causes are large amounts of antibiotics, environmental toxins, poor diet and stress.

          What are the signs of bad gut health?

          Symptoms of imbalanced gut health include frequent digestive problems, poor skin condition, respiratory problems, difficulty concentrating and joint and muscle pain.

          How do I boost my gut health?

          Probiotics, prebiotics and resistant starches can help with imbalanced gut flora and promote good gut health. They are found in certain foods such as kefir, sauerkraut, cooled potatoes and in food supplements. Probiotics – that is, foods and supplements containing living microorganisms, are considered particularly effective. 


          [1]        Bischoff, S. C. Gut health: a new objective in medicine?’, BMC Medicine, vol. 9(1), Dec. 2011, doi: 10.1186/1741-7015-9-24.

          [2]           Darmgesundheit – mehr als nur eine gute Verdauung’. Deutsche Gesellschaft für Mukosale Immunologie und Mikrobiom, available at http://www.dgmim.de/fileadmin/CONTENT/Darmgesundheit_mehr_als_nur_eine_gute_Verdauung_final.pdf, accessed on 9 July 2018. [Online].

          [3]        Haller, D., Hörmannsperger, G. Aufbau und Funktionen des Darmes’, Darmgesundheit und Mikrobiota, Wiesbaden: Springer Fachmedien Wiesbaden, 2015, p. 3–12.

          [4]        Biesalski, H.-K., Grimm, P., Nowitzki-Grimm, S. Taschenatlas Ernährung, 7., unrevised edition. Stuttgart New York: Georg Thieme Verlag, 2017.

          [5]       See How Bacteria Plays a Role in Depression, Obesity, Spinal Cord Recover + More Conditions’, Dr. Axe, Oct. 22 2016, available at https://draxe.com/gut-bacteria-benefits/, accessed on 16 July 2018.

          [6]        Honda, K., Littman, D. R. The microbiome in infectious disease and inflammation’, Annu. Rev. Immunol., vol. 30, p. 759–795, 2012, doi: 10.1146/annurev-immunol-020711-074937.

          [7]        Kasper, H., Burghardt, W. Ernährungsmedizin und Diätetik, 12., revised edition München: Elsevier, Urban & Fischer, 2014.

          [8]        Xu, X.-R. Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease’, World Journal of Gastroenterology, vol. 20(12), p. 3255, 2014, doi: 10.3748/wjg.v20.i12.3255.

          [9]        Savadogo, A., Ouattara, A. C., Bassole, H. I., Traore, S. A. Bacteriocins and lactic acid bacteria - a minireview’, African Journal of Biotechnology, vol. 5(9), Jan. 2006, accessed on 24 July 2018. [Online]

          [10]      Tanca A. et al. Potential and active functions in the gut microbiota of a healthy human cohort’, Microbiome, vol. 5(1), Dec. 2017, doi: 10.1186/s40168-017-0293-3.

          [11]      Nishida, A. Inoue, R., Inatomi, O., Bamba, S., Naito, Y., Andoh, A. Gut microbiota in the pathogenesis of inflammatory bowel disease’, Clin J Gastroenterol, Dec. 2017, doi: 10.1007/s12328-017-0813-5.

          [12]      Ernährungs UmschauMikroben verhindern Allergien’, 13 July 2015, available at https://www.ernaehrungs-umschau.de/news/13-07-2015-mikroben-verhindern-allergien/, accessed on 25 July 2018.

          [13]      Qin, J. et al., A human gut microbial gene catalogue established by metagenomic sequencing’, Nature, vol. 464(7285), p. 59–65, March 2010, doi: 10.1038/nature08821.

          [14]      Zoetendal, E. G., Akkermans, A. D., De Vos, W. M. Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria’, Appl. Environ. Microbiol., vol. 64(10), 3854–3859, Oct. 1998.

          [15]      Hawrelak, J. A., Myers, S. P. The causes of intestinal dysbiosis: a review’, Altern Med Rev, vol. 9(2), p. 180–197, June 2004.

          [16]     Darmbarriere – Zielstruktur für die Behandlung von Krankheiten :: Deutsche Gesellschaft für mukosale Immunologie und Mikrobiom’, available at  http://www.dgmim.de/index.php?id=221, accessed 9 July 2018.

          [17]      Dethlefsen, L., Huse, S., Sogin, M. L., Relman, D. A. The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing’, PLoS Biology, vol. 6(11), p. e280, Nov. 2008, doi: 10.1371/journal.pbio.0060280.

          [18]      Klein, E. Y. et al.Global increase and geographic convergence in antibiotic consumption between 2000 and 2015’, Proceedings of the National Academy of Sciences, vol. 115(15), p. E3463–E3470, Apr. 2018, doi: 10.1073/pnas.1717295115.

          [19]     Antibiotic resistance’, World Health Organization, available at http://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance, accessed on 24 July 2018.

          [20]      Bätzing-Feigenbaum, J., Schulz, M., Hering, R., Kern, W. V. Outpatient Antibiotic Prescription’, Deutsches Aerzteblatt Online, July 2016, doi: 10.3238/arztebl.2016.0454.

          [21]      Bätzing-Feigenbaum, J., Schulz, M., Hering, R., Gisbert-Miralles, J., Kern, W. V. Entwicklung des Antibiotikaverbrauchs in der ambulanten vertragsärztlichen Versorgung’, Zentralinstitut für die kassenärztliche Versorgung in Deutschland (Zi), Berlin, 18, doi: 10.20364/va-15.15.

          [22]      Bischoff, S., Koletzko, B., Lochs, H., Meier, R., DGEM Steering Committee, S3-Leitlinie der Deutschen Gesellschaft für Ernährungsmedizin (DGEM) in Zusammenarbeit mit der Gesellschaft für klinische Ernährung der Schweiz (GESKES), der Österreichischen Arbeitsgemeinschaft für klinische Ernährung (AKE) und der Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)’, Aktuelle Ernährungsmedizin, vol. 39(3), p. e72–e98, June 2014, doi: 10.1055/s-0034-1370084.

          [23]      Farnworth, E. R., Handbook of fermented functional foods. Boca Raton: CRC Press, 2008.

          [24]     Gesunde Lebensmittel? | Verbraucherzentrale Hamburg’, available at https://www.vzhh.de/themen/lebensmittel-ernaehrung/gesunde-lebensmittel, accessed on 24 July 2018.

          [25]      Quigley, E. M. M.  Prebiotics and probiotics: their role in the management of gastrointestinal disorders in adults’, Nutr Clin Pract, vol. 27(2), p. 195–200, Apr. 2012, doi: 10.1177/0884533611423926.

          [26]      Orel, R. Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease’, World Journal of Gastroenterology, vol. 20(33), p. 11505, 2014, doi: 10.3748/wjg.v20.i33.11505.

          [27]      Keenan, M. J. et al., Role of Resistant Starch in Improving Gut Health, Adiposity, and Insulin Resistance’, Advances in Nutrition, vol. 6(2), p. 198–205, March 2015, doi: 10.3945/an.114.007419.

          [28]      Rimbach, G., Nagursky, J., Erbersdobler, H. F. Lebensmittel-Warenkunde für Einsteiger. Springer-Verlag.

          [29]      Hildebrandt, M. A. et al. High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity’, Gastroenterology, vol. 137(5), p. 1716-1724.e2, Nov. 2009, doi: 10.1053/j.gastro.2009.08.042.

          [30]      Biesalski, H.-K., Adolph, M. Ernährungsmedizin: nach dem neuen Curriculum Ernährungsmedizin der Bundesärztekammer ; 276 Tabellen, 4., fully revised and extended edition, Stuttgart: Thieme, 2010.

          [31]     Reizdarmsyndrom - Darmflora rückt in den Focus : Deutsche Gesellschaft für mukosale Immunologie und Mikrobiom’, available at http://www.dgmim.de/index.php?id=223, accessed on 25 July 2018.

          [32]      Ng, S. C. et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies’, The Lancet, vol. 390(10114), p. 2769–2778, Dec. 2017, doi: 10.1016/S0140-6736(17)32448-0.

          [33]      Baker, P. I., Love, D. R., Ferguson, L. R. Role of gut microbiota in Crohn’s disease’, Expert Rev Gastroenterol Hepatol, vol. 3(5), p. 535–546, Oct. 2009, doi: 10.1586/egh.09.47.

          [34]      Haller, D. Nutrigenomics and IBD: the intestinal microbiota at the cross-road between inflammation and metabolism’, J. Clin. Gastroenterol., vol. 44 Suppl 1, p. S6–9, Sep. 2010, doi: 10.1097/MCG.0b013e3181dd8b76.

          [35]      Xu, X.-R., Liu, C.-Q., Feng, B.-S., Lui, Z.-J. Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease’, World Journal of Gastroenterology, vol. 20(12), p. 3255, 2014, doi: 10.3748/wjg.v20.i12.3255.

          [36]      Zhou, M., He, J., Shen, Y., Zhang, C., Wang, J., Chen, Y. New Frontiers in Genetics, Gut Microbiota, and Immunity: A Rosetta Stone for the Pathogenesis of Inflammatory Bowel Disease’, BioMed Research International, vol. 2017, p. 1–17, 2017, doi: 10.1155/2017/8201672.

          [37]      Kato, K. et al. Randomized placebo-controlled trial assessing the effect of bifidobacteria-fermented milk on active ulcerative colitis’, Alimentary Pharmacology and Therapeutics, vol. 20(10), p. 1133–1141, Nov. 2004, doi: 10.1111/j.1365-2036.2004.02268.x.

          [38]      Cui, H.-H. et al. Effects of probiotic on intestinal mucosa of patients with ulcerative colitis’, World J. Gastroenterol., vol. 10(10), p. 1521–1525, May 2004.

          [39]      Foster, J. A. Gut feelings: bacteria and the brain’, Cerebrum, vol. 2013, p. 9, 2013.

          [40]      Huang, R., Wang, K., Hu, J. Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials’, Nutrients, vol. 8(8), p. 483, Aug. 2016, doi: 10.3390/nu8080483.

          [41]      Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., Gordon, J. I., Human nutrition, the gut microbiome and the immune system’, Nature, vol. 474(7351), p. 327–336, June 2011, doi: 10.1038/nature10213.

          [42]      Al-Ghazzewi, F. H., Tester, R. F. Impact of prebiotics and probiotics on skin health’, Beneficial Microbes, vol. 5(2), 99–107, June 2014, doi: 10.3920/BM2013.0040.

          [43]     ‘Digesting the facts: what people are thinking about their digestive health’, Guts Charity UK (formerly Core), available at http://gutscharity.org.uk/wp-content/uploads/2016/08/DigestingTheFactsReport.pdf, accessed on 31 March 2021.

          [44]     ‘Irritable bowel syndrome (IBS), BUPA, available at https://www.bupa.co.uk/health-information/digestive-gut-health/irritable-bowel-syndrome#:~:text=About%20irritable%20bowel%20syndrome,re%20between%2020%20and%2030, accessed on 31 March 2021.


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